Trifluoroacetic acid → HCID 178447009, 화합물

HRID 1010970노트

반응식

HRID 1010970 반응식
[CH3:1][CH:2]([O:6][C:7]1[N:15]=[C:14]2[C:10]([N:11]=[C:12]([O:22][CH3:23])[N:13]2C2CCCCO2)=[C:9]([NH2:24])[N:8]=1)[CH2:3][CH2:4][CH3:5].[C:25]([OH:31])([C:27]([F:30])([F:29])[F:28])=[O:26]>CO>[F:28][C:27]([F:30])([F:29])[C:25]([OH:31])=[O:26].[CH3:1][CH:2]([O:6][C:7]1[N:15]=[C:14]2[C:10]([N:11]=[C:12]([O:22][CH3:23])[NH:13]2)=[C:9]([NH2:24])[N:8]=1)[CH2:3][CH2:4][CH3:5]

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 576997022-[(1-Methylbutyl)oxy]-8-methoxy-9-(tetrahydro-2H-pyran-2-yl)-9H-Purin-6-amine

생성물 1

HCID 178447009HCID 178447009, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of 2-[(1-methylbutyl)oxy]-8-methoxy-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine (313 mg) in dry MeOH (3.13 mL) was added TFA (0.313 mL) and the mixture was stirred at room temperature for 48 h. The reaction mixture was concentrated in vacuo to give a yellow residue which was triturated with Et2O and filtered to give the title compound as an off-white solid (218 mg).

후처리

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. customto give a yellow residue which
  3. customwas triturated with Et2O
  4. filtrationfiltered

출처 및 근거

ORD 기록
ord-5c8bbd0f9df4412bb9bcfeb4618ca128
출처 데이터셋
uspto-grants-2011_07
특허 번호
US07977344B2

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