Trifluoroacetic acid → HCID 178493994, 화합물

HRID 1010979노트

반응식

HRID 1010979 반응식
[CH:1]1([CH2:4][CH2:5][O:6][C:7]2[N:15]=[C:14]3[C:10]([N:11]=[C:12]([O:22][CH3:23])[N:13]3C3CCCCO3)=[C:9]([NH2:24])[N:8]=2)[CH2:3][CH2:2]1.[C:25]([OH:31])([C:27]([F:30])([F:29])[F:28])=[O:26].CCOC(C)=O>CO>[F:28][C:27]([F:30])([F:29])[C:25]([OH:31])=[O:26].[CH:1]1([CH2:4][CH2:5][O:6][C:7]2[N:15]=[C:14]3[C:10]([N:11]=[C:12]([O:22][CH3:23])[NH:13]3)=[C:9]([NH2:24])[N:8]=2)[CH2:3][CH2:2]1

참가 물질

5

반응물 3

HCID 6422Trifluoroacetic acidHCID 8857Ethyl AcetateHCID 576996292-[(2-Cyclopropylethyl)oxy]-8-methoxy-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine

생성물 1

HCID 178493994HCID 178493994, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

2-[(2-Cyclopropylethyl)oxy]-8-methoxy-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine (845 mg) was dissolved in MeOH (10 mL) and TFA (1 mL) was added. The reaction was stirred over a weekend and was evaporated to dryness under reduced pressure to give a brown solid. EtOAc was added and the solid was filtered off and washed with more EtOAc (15 mL EtOAc used in total). The solid was then washed with Et2O (5 mL) and air-dried under suction to give the title compound as an off-white solid (937 mg).

후처리

  1. customwas evaporated to dryness under reduced pressure
  2. customto give a brown solid
  3. filtrationthe solid was filtered off
  4. washwashed with more EtOAc (15 mL EtOAc used in total)
  5. washThe solid was then washed with Et2O (5 mL)
  6. customair-dried under suction

출처 및 근거

ORD 기록
ord-2c46f7b4dbae404d8a52d6c3d32fde52
출처 데이터셋
uspto-grants-2011_07
특허 번호
US07977344B2

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