Triethylamine → HCID 22402475, 화합물

HRID 1010992

반응식

HRID 1010992 반응식
[O:1]1[CH2:6][CH2:5][CH2:4][CH:3]([CH2:7][OH:8])[CH2:2]1.C(N(CC)CC)C.[S:16](Cl)([CH3:19])(=[O:18])=[O:17]>ClCCl>[CH3:19][S:16]([O:8][CH2:7][CH:3]1[CH2:4][CH2:5][CH2:6][O:1][CH2:2]1)(=[O:18])=[O:17]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 85769Tetrahydro-2H-pyran-3-methanol

생성물 1

HCID 22402475HCID 22402475, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To tetrahydro-2H-pyran-3-ylmethanol (4.92 g) in dry dichloromethane (140 ml) at 0° C. and under nitrogen, was added anhydrous triethylamine (13.6 ml) in one go, followed by mesyl chloride (4.3 ml) dropwise over 5 minutes. The reaction was allowed to warm to room temperature and stirred at this temperature overnight. The reaction was quenched with saturated aqueous sodium bicarbonate (50 ml). The organic layer was separated, passed through a hydrophobic frit to dry and concentrated in vacuo to yield a red oil (8.8 g).

후처리

  1. customThe reaction was quenched with saturated aqueous sodium bicarbonate (50 ml)
  2. customThe organic layer was separated
  3. customto dry
  4. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-da1ea2a94585412492498f6165dd4248
출처 데이터셋
uspto-grants-2011_07
특허 번호
US07977344B2

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