Trifluoroacetic acid → HCID 178493992, 화합물

HRID 1011032노트

반응식

HRID 1011032 반응식
[CH3:1][O:2][C:3]1[N:4](C2CCCCO2)[C:5]2[C:10]([N:11]=1)=[C:9]([NH2:12])[N:8]=[C:7]([O:13][CH2:14][CH:15]1[CH2:19][CH2:18][CH2:17][O:16]1)[N:6]=2.[F:26][C:27]([F:32])([F:31])[C:28]([OH:30])=[O:29]>CO>[F:26][C:27]([F:32])([F:31])[C:28]([OH:30])=[O:29].[CH3:1][O:2][C:3]1[NH:4][C:5]2[C:10]([N:11]=1)=[C:9]([NH2:12])[N:8]=[C:7]([O:13][CH2:14][CH:15]1[CH2:19][CH2:18][CH2:17][O:16]1)[N:6]=2

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 576998158-(Methoxy)-2-[(tetrahydro-2-furanylmethyl)oxy]-9-(tetrahydro-2H-Pyran-2-yl)-9H-purin-6-amine

생성물 1

HCID 178493992HCID 178493992, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

8-(Methoxy)-2-[(tetrahydro-2-furanyl methyl)oxy]-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine (1.1614 g) was dissolved in methanol (20 mL) and treated with neat trifluoroacetic acid (2 mL). The reaction mixture was stirred for 24 hours to give a white suspension. The reaction mixture was then evaporated to dryness under reduced pressure. The resultant white solid was suspended using ethyl acetate (10 mL) and then isolated by filtration, washing with ethyl acetate (2 mL). The solid was air-dried under suction and then dried further under vacuo at 50° C. This gave the title compound as a white solid (1.0602 g).

후처리

  1. customto give a white suspension
  2. customThe reaction mixture was then evaporated to dryness under reduced pressure
  3. customisolated by filtration
  4. washwashing with ethyl acetate (2 mL)
  5. customThe solid was air-dried under suction
  6. customdried further under vacuo at 50° C

출처 및 근거

ORD 기록
ord-70d691defeeb4f9895a0a8af6cace0e2
출처 데이터셋
uspto-grants-2011_07
특허 번호
US07977344B2

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