Dimethylformamide → cyclopropane-1,1-dicarboxylic acid {3-fluoro-4-[6-(2-morpholin-4-yl-ethylcarbamoyl)-7-(2-trimethylsilanyl-ethoxymethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy]-phenyl}-amide(4-fluoro-phenyl)-amide

반응식

[F:1][C:2]1[CH:28]=[C:27]([NH:29][C:30]([C:32]2([C:35](=[O:44])[NH:36][C:37]3[CH:42]=[CH:41][C:40]([F:43])=[CH:39][CH:38]=3)[CH2:34][CH2:33]2)=[O:31])[CH:26]=[CH:25][C:3]=1[O:4][C:5]1[C:6]2[CH:13]=[C:12]([C:14](O)=[O:15])[N:11]([CH2:17][O:18][CH2:19][CH2:20][Si:21]([CH3:24])([CH3:23])[CH3:22])[C:7]=2[N:8]=[CH:9][N:10]=1.[N:45]1([CH2:51][CH2:52][NH2:53])[CH2:50][CH2:49][O:48][CH2:47][CH2:46]1.CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.CN(C=O)C>C(OCC)(=O)C>[F:43][C:40]1[CH:41]=[CH:42][C:37]([NH:36][C:35]([C:32]2([C:30]([NH:29][C:27]3[CH:26]=[CH:25][C:3]([O:4][C:5]4[C:6]5[CH:13]=[C:12]([C:14](=[O:15])[NH:53][CH2:52][CH2:51][N:45]6[CH2:50][CH2:49][O:48][CH2:47][CH2:46]6)[N:11]([CH2:17][O:18][CH2:19][CH2:20][Si:21]([CH3:23])([CH3:22])[CH3:24])[C:7]=5[N:8]=[CH:9][N:10]=4)=[C:2]([F:1])[CH:28]=3)=[O:31])[CH2:33][CH2:34]2)=[O:44])=[CH:38][CH:39]=1