Methanol → HCID 58478790, 화합물
반응식
[CH3:1][O:2][CH:3]=[CH:4][C:5]1[N:10]=[C:9]2[CH2:11][O:12][C:13](=[O:14])[C:8]2=[CH:7][CH:6]=1.[CH3:15][OH:16]>S(=O)(=O)(O)O>[CH3:1][O:2][CH:3]([O:16][CH3:15])[CH2:4][C:5]1[N:10]=[C:9]2[CH2:11][O:12][C:13](=[O:14])[C:8]2=[CH:7][CH:6]=1참가 물질
4
반응 조건
- 온도
- 70 °C
실험 절차
To a solution of 2-(2-methoxy-vinyl)-7H-furo[3,4-b]pyridin-5-one (108 mg, 0.57 mmol) in anhydrous MeOH (10 mL) is added three drops of concentrated sulfuric acid. The reaction solution is stirred and heated at 70° C. for 18 h at which time the starting material is consumed. The reaction mixture is then diluted with EtOAc (100 mL), and then washed with saturated aqueous NaHCO3 (2×75 mL). The organic solution is dried (Na2SO4) and concentrated to give the title compound as a brown oil (104 mg, 83%).
후처리
- customis consumed
- additionThe reaction mixture is then diluted with EtOAc (100 mL)
- washwashed with saturated aqueous NaHCO3 (2×75 mL)
- dry with materialThe organic solution is dried (Na2SO4)
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-996aecdf31b64acf83eae33a05ba8ef6
- 출처 데이터셋
- uspto-grants-2011_07
- 특허 번호
- US07977351B2
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