Ethanol → HCID 135819170, 화합물

HRID 1011423노트

반응식

HRID 1011423 반응식
[OH:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[C:7]([C:12]([OH:14])=[O:13])[CH:8]=[N:9]2)=[CH:4][CH:3]=1.O=S(Cl)Cl.O.C([O-])([O-])=O.[Na+].[Na+].[CH3:26][CH2:27]O>>[OH:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[C:7]([C:12]([O:14][CH2:26][CH3:27])=[O:13])[CH:8]=[N:9]2)=[CH:4][CH:3]=1

참가 물질

6

반응물 5

HCID 702EthanolHCID 962WaterHCID 10340Sodium CarbonateHCID 24386Thionyl ChlorideHCID 1361076117-Hydroxyquinoline-3-carboxylic acid

생성물 1

HCID 135819170HCID 135819170, 화합물수율 64%

실험 절차

To a solution of the compound obtained in stage A (15 g, 79 mmol) in EtOH (500 ml) was added dropwise SOCl2 (40 mL). The resulting mixture was stirred under reflux during 12 hours. After adding water (200 mL), the pH was adjusted to 7.0 with 20% aqueous Na2CO3. The aqueous solution was extracted with CH2Cl2 (3×200 mL). The combined organic layers were dried over MgSO4, filtered and evaporated to afford 11 g (yield: 64%) of the product of molecular formula C12H11NO3. Aspect: pale brown powder.

후처리

  1. temperatureunder reflux during 12 hours
  2. extractionThe aqueous solution was extracted with CH2Cl2 (3×200 mL)
  3. dry with materialThe combined organic layers were dried over MgSO4
  4. filtrationfiltered
  5. customevaporated

출처 및 근거

ORD 기록
ord-906707339050480d8e32e713657091ad
출처 데이터셋
uspto-grants-2011_07
특허 번호
US07977354B2

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