HCID 23159744, 화합물 → ethyl 5-hydroxyquinoline-3-carboxylate

HRID 1011424노트

반응식

HRID 1011424 반응식
C([O:8][C:9]1[CH:18]=[CH:17][CH:16]=[C:15]2[C:10]=1[CH:11]=[C:12]([C:19]([O:21][CH2:22][CH3:23])=[O:20])[CH:13]=[N:14]2)C1C=CC=CC=1>C(O)C.[Pd]>[OH:8][C:9]1[CH:18]=[CH:17][CH:16]=[C:15]2[C:10]=1[CH:11]=[C:12]([C:19]([O:21][CH2:22][CH3:23])=[O:20])[CH:13]=[N:14]2

참가 물질

4

반응물 1

HCID 23159744HCID 23159744, 화합물

생성물 1

HCID 135618214ethyl 5-hydroxyquinoline-3-carboxylate수율 91.4%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

210 mg (0.68 mmol) of compound prepared in stage B dissolved in 25 mL of ethanol was stirred in presence of Pd/C5% (75 mg, 0.034 mmol) under an atmosphere of hydrogen for 3 hours. The palladium was then removed by filtration and ethanol was evaporated under reduced pressure. The 1H NMR of the crude product showed a part of a reduced by-product at the pyridine ring (dihydroquinoline derivatives). The mixture was dissolved in ethanol and treated with air gas until complete re-oxidation of the product. Evaporation of the solvent gave 135 mg (yield: 91%) of compound of molecular formula C12H11NO3. Aspect: yellow powder.

후처리

  1. customThe palladium was then removed by filtration and ethanol
  2. customwas evaporated under reduced pressure
  3. dissolutionThe mixture was dissolved in ethanol
  4. additiontreated with air gas until complete re-oxidation of the product
  5. customEvaporation of the solvent

출처 및 근거

ORD 기록
ord-0cc5bf39712843f3a1246f369c8571fd
출처 데이터셋
uspto-grants-2011_07
특허 번호
US07977354B2

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