Benzyl Bromide → HCID 23159744, 화합물

HRID 1011425노트

반응식

HRID 1011425 반응식
[OH:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[C:5]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH:6]=[N:7]2.C([O-])([O-])=O.[Na+].[Na+].[CH2:23](Br)[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>CN(C=O)C.O>[CH2:23]([O:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[C:5]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH:6]=[N:7]2)[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1

참가 물질

6

반응물 3

HCID 7498Benzyl BromideHCID 10340Sodium CarbonateHCID 135618214ethyl 5-hydroxyquinoline-3-carboxylate

생성물 1

HCID 23159744HCID 23159744, 화합물

시약·촉매·용매 2

HCID 962Water용매HCID 6228Dimethylformamide용매

실험 절차

A solution of ethyl 5-hydroxyquinoline-3-carboxylate (2.17 g, 10 mmol) prepared in stage D of example 2, Na2CO3 (2.12 g, 20 mmol) and benzylbromide (1.71 g, 10 mmol) in DMF (20 mL) was stirred for 12 hours at room temperature. The reaction mixture was diluted with water (50 mL) and then extracted with AcOEt (3×25 mL). The combined organic layers were washed water, and dried over Magnesium sulfate and evaporated under reduced pressure. The obtained residue was chromatographed over silica-gel.

후처리

  1. extractionextracted with AcOEt (3×25 mL)
  2. washThe combined organic layers were washed water
  3. dry with materialdried over Magnesium sulfate
  4. customevaporated under reduced pressure
  5. customThe obtained residue was chromatographed over silica-gel

출처 및 근거

ORD 기록
ord-b6cf759d46af4eefb72a608bfe7a8487
출처 데이터셋
uspto-grants-2011_07
특허 번호
US07977354B2

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