Boron tribromide → 7-Hydroxy-3-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)quinoline

HRID 1011428노트

반응식

HRID 1011428 반응식
C[O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH:7]=[C:8]([C:13]3[O:14][CH2:15][C:16]([CH3:19])([CH3:18])[N:17]=3)[CH:9]=[N:10]2)=[CH:5][CH:4]=1.B(Br)(Br)Br>ClCCl>[OH:2][C:3]1[CH:12]=[C:11]2[C:6]([CH:7]=[C:8]([C:13]3[O:14][CH2:15][C:16]([CH3:19])([CH3:18])[N:17]=3)[CH:9]=[N:10]2)=[CH:5][CH:4]=1

참가 물질

4

반응물 2

HCID 25134Boron tribromideHCID 231597597-Methoxy-3-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)quinoline

생성물 1

HCID 1356182107-Hydroxy-3-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)quinoline

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution of 7-methoxy-3-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)quinoline (2.56 g, 10 mmol) prepared in stage A and BBr3 (7.41 g, 30 mmol) in dichloromethane (40 mL) are stirred for 12 hours at room temperature. The mixture was quenched with saturated sodium hydrogen carbonate. Extraction with dichloromethane, drying (MgSO4) and evaporation furnished the desired compound.

후처리

  1. customThe mixture was quenched with saturated sodium hydrogen carbonate
  2. extractionExtraction with dichloromethane
  3. customdrying
  4. custom(MgSO4) and evaporation

출처 및 근거

ORD 기록
ord-f08bfad8e287479db8bc5f23ab85c845
출처 데이터셋
uspto-grants-2011_07
특허 번호
US07977354B2

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