Ammonium Chloride → HCID 86761357, 화합물

HRID 1011432노트

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HRID 1011432 반응식
Br[C:2]1[CH:3]=[N:4][C:5]2[C:10]([CH:11]=1)=[C:9]([O:12][CH3:13])[CH:8]=[CH:7][CH:6]=2.[CH:14]([Mg]Cl)([CH3:16])[CH3:15].[CH:19]1(C)CC[CH:22](C(C)C)[CH:21]([S:28]([O-])=[O:29])[CH2:20]1.[NH4+].[Cl-]>C1COCC1>[CH3:15][C:14]1[CH:16]=[CH:22][C:21]([S:28]([C:2]2[CH:3]=[N:4][C:5]3[C:10]([CH:11]=2)=[C:9]([O:12][CH3:13])[CH:8]=[CH:7][CH:6]=3)=[O:29])=[CH:20][CH:19]=1

참가 물질

6

반응물 4

HCID 25517Ammonium ChlorideHCID 231597643-Bromo-5-methoxyquinolineHCID 66813815HCID 66813815, 화합물HCID 178418918HCID 178418918, 화합물

생성물 1

HCID 86761357HCID 86761357, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

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온도
-78 °C

실험 절차

To a solution 3-bromo-5-methoxyquinoline (2.37, 10 mmol) prepared in stage B in dried THF (35 mL) is added a solution of isopropylmagnesium chloride (16.6 mL, 30 mmol) at −78° C. The solution is stirred at −78° C. under nitrogen atmosphere for 3 hours. Menthyl sulfinate (8.8 g, 30 mmol) is added and the resulting solution is stirred for a further 24 hours. The reaction mixture is then hydrolysed with saturated aqueous NH4Cl solution. After extraction of the aqueous phase, the combined organic layers are dried (MgSO4), evaporated giving the title compound.

후처리

  1. stirringthe resulting solution is stirred for a further 24 hours
  2. extractionAfter extraction of the aqueous phase
  3. dry with materialthe combined organic layers are dried (MgSO4)
  4. customevaporated

출처 및 근거

ORD 기록
ord-7e24c7eea64c44bf94d44785c0ff3d2d
출처 데이터셋
uspto-grants-2011_07
특허 번호
US07977354B2

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