Dimethyl Disulfide → HCID 23159742, 화합물

HRID 1011434노트

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HRID 1011434 반응식
Br[C:2]1[CH:3]=[N:4][C:5]2[C:10]([CH:11]=1)=[C:9]([O:12][CH3:13])[CH:8]=[CH:7][CH:6]=2.[CH3:14][S:15]SC>C1COCC1>[CH3:13][O:12][C:9]1[CH:8]=[CH:7][CH:6]=[C:5]2[C:10]=1[CH:11]=[C:2]([S:15][CH3:14])[CH:3]=[N:4]2

참가 물질

4

반응물 2

HCID 12232Dimethyl DisulfideHCID 231597643-Bromo-5-methoxyquinoline

생성물 1

HCID 23159742HCID 23159742, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
-78 °C

실험 절차

To a solution of 3-bromo-5-methoxy quinoline (2.37 g, 10 mmol) prepared in stage B of example 10 in THF (25 mL) was added 2.5M n-buLi (4 mL, 10 mmol) at −78° C. The solution is stirred at −78° C. for 45 min and dimethyl disulfide (1.8 g, 20 mmol) is added. The resultant solution is stirred for 3 hours and then quenched with saturated NH4Cl (30 mL). Extraction with dichloromethane, drying, filtering and evaporation in vacuo afford the title compound

후처리

  1. customquenched with saturated NH4Cl (30 mL)
  2. extractionExtraction with dichloromethane
  3. customdrying
  4. filtrationfiltering
  5. customevaporation in vacuo

출처 및 근거

ORD 기록
ord-602bdd1194b34418b09bb0bb9e75ce08
출처 데이터셋
uspto-grants-2011_07
특허 번호
US07977354B2

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