참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 1-Bromoisoquinoline | HCID 640963 | — |
| 반응물 | 2-Methoxyphenylboronic acid | HCID 2733958 | — |
| 촉매 | HCID 178418397 | HCID 178418397 | — |
| 용매 | N,N-Dimethylformamide--water (1/1) | HCID 21962138 | — |
| 생성물 | 1-(2-Methoxyphenyl)isoquinoline | HCID 23159734 | — |
반응 단계
A solution of 1-bromoisoquinoline (2.06 g, 10 mmol), prepared as described in European Journal of Organic Chemistry 2002, 4181-4184, 2-methoxyphenylboronic acid (2.79 g, 10 mmol), Pd(PPh3)4 (5% mol), K2CO3 (5 g) in DMF/water (3/1) is stirred at 50° C. for 12 hours. The reaction mixture is then pored on water (150 mL). The aqueous phase is extracted with ethyl acetate (3×100 mL). The combined organic layers are washed with water (3×200 mL). The organic phase is dried over magnesium sulfate and evaporated under vacuum to afford the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07977354B2 |
|---|
| 출처 데이터셋 | uspto-grants-2011_07 |
|---|
| ORD ID | ord-e12ca8df30494583a4d54d1c6152a1db |
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| 출처 메모 | uspto-grants-2011_07 |
|---|
