Water → 2-Aminocarbonylamino-5-(4-bromophenyl)-4-chloropyrrole-3-carboxamide

HRID 1011577노트

반응식

HRID 1011577 반응식
[Cl:1]N1C(=O)CCC1=O.[NH2:9][C:10]([NH:12][C:13]1[NH:14][C:15]([C:21]2[CH:26]=[CH:25][C:24]([Br:27])=[CH:23][CH:22]=2)=[CH:16][C:17]=1[C:18]([NH2:20])=[O:19])=[O:11].O>CN(C)C=O>[NH2:9][C:10]([NH:12][C:13]1[NH:14][C:15]([C:21]2[CH:26]=[CH:25][C:24]([Br:27])=[CH:23][CH:22]=2)=[C:16]([Cl:1])[C:17]=1[C:18]([NH2:20])=[O:19])=[O:11]

참가 물질

5

반응물 3

HCID 962WaterHCID 31398ChlorosuccinimideHCID 250057042-Aminocarbonylamino-5-(4-bromophenyl)pyrrole-3-carboxamide

생성물 1

HCID 592858832-Aminocarbonylamino-5-(4-bromophenyl)-4-chloropyrrole-3-carboxamide수율 51%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

N-Chlorosuccinimide (48 mg, 0.36 mmol) was added to a solution of 2-aminocarbonylamino-5-(4-bromophenyl)pyrrole-3-carboxamide (Compound No. 1-1, 97 mg, 0.30 mmol) in anhydrous N,N-dimethylformamide (2 mL), and the mixture was stirred overnight at 50° C. After cooling, water (4 mL) was added thereto, the precipitated solid was filtered off, and washed with water (5 mL). The obtained solid was dried under reduced pressure to give the target compound (54 mg) as a pale brown solid (Yield 51%).

후처리

  1. temperatureAfter cooling
  2. filtrationthe precipitated solid was filtered off
  3. washwashed with water (5 mL)
  4. customThe obtained solid was dried under reduced pressure

출처 및 근거

ORD 기록
ord-4d0288762c754547860d5c69e09d62bf
출처 데이터셋
uspto-grants-2011_07
특허 번호
US07977371B2

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