2-Aminocarbonylamino-5-(4-vinylphenyl)pyrrole-3-carboxamide → 2-Aminocarbonylamino-5-(4-ethylphenyl)pyrrole-3-carboxamide

HRID 1011582노트

반응식

HRID 1011582 반응식
[NH2:1][C:2]([NH:4][C:5]1[NH:6][C:7]([C:13]2[CH:18]=[CH:17][C:16]([CH:19]=[CH2:20])=[CH:15][CH:14]=2)=[CH:8][C:9]=1[C:10]([NH2:12])=[O:11])=[O:3]>[Pd].CO>[NH2:1][C:2]([NH:4][C:5]1[NH:6][C:7]([C:13]2[CH:18]=[CH:17][C:16]([CH2:19][CH3:20])=[CH:15][CH:14]=2)=[CH:8][C:9]=1[C:10]([NH2:12])=[O:11])=[O:3]

참가 물질

4

반응물 1

HCID 250029182-Aminocarbonylamino-5-(4-vinylphenyl)pyrrole-3-carboxamide

생성물 1

HCID 592858602-Aminocarbonylamino-5-(4-ethylphenyl)pyrrole-3-carboxamide수율 62.2%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

10% Palladium on activated carbon (6 mg) was added to a solution of 2-aminocarbonylamino-5-(4-vinylphenyl)pyrrole-3-carboxamide (Compound No. 9-1, 16 mg, 0.059 mmol) in methanol (2 mL) and the mixture was stirred at room temperature for 4.5 hours under hydrogen gas atmosphere. After the reaction solution was filtered, the filterate was concentrated in vacuo. The obtained solid was washed with diethyl ether (2 mL) and dried under reduced pressure to give the target compound (10 mg) as a colorless solid (Yield 62%).

후처리

  1. filtrationAfter the reaction solution was filtered
  2. concentrationthe filterate was concentrated in vacuo
  3. washThe obtained solid was washed with diethyl ether (2 mL)
  4. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-ec598e5e53524e5fa5571f59ffa87c96
출처 데이터셋
uspto-grants-2011_07
특허 번호
US07977371B2

반응 노트

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