Citric Acid → 1-butyl-N,N-dimethyl-4,4-bis(3-methyl-5-(trifluoromethyl)-1H-indol-2-yl)cyclohexanamine 2-hydroxypropane-1,2,3-tricarboxylate

HRID 1011622노트

반응식

HRID 1011622 반응식
[CH2:1]([C:5]1([N:39]([CH3:41])[CH3:40])[CH2:10][CH2:9][C:8]([C:25]2[NH:26][C:27]3[C:32]([C:33]=2[CH3:34])=[CH:31][C:30]([C:35]([F:38])([F:37])[F:36])=[CH:29][CH:28]=3)([C:11]2[NH:12][C:13]3[C:18]([C:19]=2[CH3:20])=[CH:17][C:16]([C:21]([F:24])([F:23])[F:22])=[CH:15][CH:14]=3)[CH2:7][CH2:6]1)[CH2:2][CH2:3][CH3:4].[C:42]([OH:54])(=[O:53])[CH2:43][C:44]([CH2:49][C:50]([OH:52])=[O:51])([C:46]([OH:48])=[O:47])[OH:45]>C(O)C>[OH:45][C:44]([C:46]([OH:48])=[O:47])([CH2:49][C:50]([OH:52])=[O:51])[CH2:43][C:42]([OH:54])=[O:53].[CH2:1]([C:5]1([N:39]([CH3:41])[CH3:40])[CH2:10][CH2:9][C:8]([C:11]2[NH:12][C:13]3[C:18]([C:19]=2[CH3:20])=[CH:17][C:16]([C:21]([F:22])([F:24])[F:23])=[CH:15][CH:14]=3)([C:25]2[NH:26][C:27]3[C:32]([C:33]=2[CH3:34])=[CH:31][C:30]([C:35]([F:38])([F:36])[F:37])=[CH:29][CH:28]=3)[CH2:7][CH2:6]1)[CH2:2][CH2:3][CH3:4]

참가 물질

4

반응물 2

HCID 311Citric AcidHCID 445175681-butyl-N,N-dimethyl-4,4-bis(3-methyl-5-(trifluoromethyl)-1H-indol-2-yl)cyclohexanamine

생성물 1

HCID 445175671-butyl-N,N-dimethyl-4,4-bis(3-methyl-5-(trifluoromethyl)-1H-indol-2-yl)cyclohexanamine 2-hydroxypropane-1,2,3-tricarboxylate

시약·촉매·용매 1

HCID 702Ethanol용매2회

실험 절차

1-butyl-N,N-dimethyl-4,4-bis(3-methyl-5-(trifluoromethyl)-1H-indol-2-yl)cyclohexanamine (100 mg, 0.17 mmol) was dissolved in ethanol (10 ml) and mixed with citric acid (36 mg, 0.187 mmol) dissolved in hot ethanol (3 ml). The clear colourless solution was stirred for 48 h and then concentrated to low volume. After adding diethyl ether (10 ml), the mixture was stirred for 2 h at RT and the precipitate was then aspirated.

후처리

  1. concentrationconcentrated to low volume
  2. additionAfter adding diethyl ether (10 ml)
  3. stirringthe mixture was stirred for 2 h at RT

출처 및 근거

ORD 기록
ord-7dd5d2d7c7404608aa092da276995103
출처 데이터셋
uspto-grants-2011_07
특허 번호
US07977370B2

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