반응식
[CH3:1][C:2]([Si:5]([CH3:37])([CH3:36])[O:6][CH2:7][C@@H:8]([O:10][C:11]1[CH:12]=[C:13]([CH:25]=[C:26]([O:28]CC2C=CC=CC=2)[CH:27]=1)[C:14]([NH:16][C:17]1[CH:21]=[CH:20][N:19]([CH:22]([CH3:24])[CH3:23])[N:18]=1)=[O:15])[CH3:9])([CH3:4])[CH3:3]>C1COCC1>[CH3:1][C:2]([Si:5]([CH3:37])([CH3:36])[O:6][CH2:7][C@@H:8]([O:10][C:11]1[CH:12]=[C:13]([CH:25]=[C:26]([OH:28])[CH:27]=1)[C:14]([NH:16][C:17]1[CH:21]=[CH:20][N:19]([CH:22]([CH3:24])[CH3:23])[N:18]=1)=[O:15])[CH3:9])([CH3:4])[CH3:3]참가 물질
3
반응물 1
생성물 1
시약·촉매·용매 1
실험 절차
A solution of 3-[((1S)-2-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-1-methylethyl)oxy]-N-[1-(1-methylethyl)-1H-pyrazol-3-yl]-5-[(phenylmethyl)oxy]benzamide (1.97 g, 3.77 mmol) and THF (70 mL) was evacuated and purged with Argon (×3). Palladium on carbon (10% w/w, 400 mg) was added and reaction mixture was evacuated and finally purged with hydrogen gas. Reaction mixture was left to stir at ambient temperature under hydrogen for 16 hours. The palladium on carbon was filtered off and concentrated in vacuo to give the product as a colourless oil (1.58 g, 97%).
후처리
- custompurged with Argon (×3)
- additionPalladium on carbon (10% w/w, 400 mg) was added
- customreaction mixture
- customwas evacuated
- customfinally purged with hydrogen gas
- customReaction mixture
- waitwas left
- filtrationThe palladium on carbon was filtered off
- concentrationconcentrated in vacuo
출처 및 근거
- ORD 기록
- ord-e9e9aa55643548eca3c0251b0eeefe89
- 출처 데이터셋
- uspto-grants-2011_07
- 특허 번호
- US07977328B2
연결된 노트
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