Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3,4-Dichlorobenzeneboronic acid → [5-(3',4'-dichloro-biphenyl-3-yl)-1,4-dimethyl-1H-pyrazol-3-yl]-(3-diethylamino-pyrrolidin-1-yl)-methanone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3,4-Dichlorobenzeneboronic acid | HCID 2734330 | — |
| 반응물 | [5-(3-bromo-phenyl)-1,4-dimethyl-1H-pyrazol-3-yl]-(3-diethylamino-pyrrolidin-1-yl)-methanone | HCID 67315151 | — |
| 생성물 | [5-(3',4'-dichloro-biphenyl-3-yl)-1,4-dimethyl-1H-pyrazol-3-yl]-(3-diethylamino-pyrrolidin-1-yl)-methanone | HCID 57554968 | 55% |
반응 단계
In analogy to the procedure described in example 14C], [5-(3-bromo-phenyl)-1,4-dimethyl-1H-pyrazol-3-yl]-(3-diethylamino-pyrrolidin-1-yl)-methanone and 3,4-dichlorophenylboronic acid gave [5-(3′,4′-dichloro-biphenyl-3-yl)-1,4-dimethyl-1H-pyrazol-3-yl]-(3-diethylamino-pyrrolidin-1-yl)-methanone in 55% yield as light brown foam. MS: 485.2 (MH+, 2 Cl).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07977358B2 |
| 출처 데이터셋 | uspto-grants-2011_07 |
| ORD ID | ord-d15b8aff07b74f91a3be06d4c810f089 |
| 출처 메모 | uspto-grants-2011_07 |