Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
(2-Cyclohexylvinyl)boronic acid → {1-[3-((E)-2-Cyclohexyl-vinyl)-phenyl]-3,5-dimethyl-1H-pyrazol-4-yl]-(3-diethylamino-pyrrolidin-1-yl)-methanone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | (2-Cyclohexylvinyl)boronic acid | HCID 6031024 | — |
| 반응물 | [1-(3-Bromo-phenyl)-3,5-dimethyl-1H-pyrazol-4-yl]-(3-diethylamino-pyrrolidin-1-yl)-methanone | HCID 67313795 | — |
| 생성물 | {1-[3-((E)-2-Cyclohexyl-vinyl)-phenyl]-3,5-dimethyl-1H-pyrazol-4-yl]-(3-diethylamino-pyrrolidin-1-yl)-methanone | HCID 57555093 | 40% |
반응 단계
In analogy to the procedure described in Example 14C], [1-(3-bromo-phenyl)-3,5-dimethyl-1H-pyrazol-4-yl]-(3-diethylamino-pyrrolidin-1-yl)-methanone (Example 30A]) and trans-2-cyclohexylvinylboronic acid gave the title compound in 40% yield as brown gum. MS: 449.3 (MH+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07977358B2 |
| 출처 데이터셋 | uspto-grants-2011_07 |
| ORD ID | ord-21da7f117ce04824ac190d90513d07c7 |
| 출처 메모 | uspto-grants-2011_07 |