Pyridine → 5-Methyl-3-pyridin-4-yl-1-(3-trifluoromethoxy-phenyl)-1H-pyrazole-4-carboxylic acid ethyl ester

A blue-green suspension of 5-methyl-3-pyridin-4-yl-1H-pyrazole-4-carboxylic acid ethyl ester (700 mg, 3.03 mmol), molecular sieves 4A, 3-(trifluoromethoxy)benzeneboronic acid (1.25 g, 6.05 mmol), copper (II) acetate (824 mg, 4.54 mmol) and pyridine (0.48 ml, 6.05 mmol) in 14 ml CH2Cl2 was stirred under argon atmosphere and at room temperature for 5 days. The reaction mixture was diluted with CH2Cl2 and washed with a saturated solution of NaHCO3 and brine. The aqueous phases were extracted twice with CH2Cl2, the combined organic layers dried over magnesium sulfate, and evaporated. The residue was treated with EtOAc:toluene, 1:9, filtered off. The filtrate was evaporated and chromatographed twice (amino-phase silica gel, toluene:EtOAc 9:1) to afford the title compound as a colorless oil (638 mg, 54%). MS: 392.1 (MH+).

1. washwashed with a saturated solution of NaHCO3 and brine
2. extractionThe aqueous phases were extracted twice with CH2Cl2
3. dry with materialthe combined organic layers dried over magnesium sulfate
4. customevaporated
5. additionThe residue was treated with EtOAc
6. filtrationtoluene, 1:9, filtered off
7. customThe filtrate was evaporated
8. customchromatographed twice (amino-phase silica gel, toluene:EtOAc 9:1)

ORD 기록

ord-5fbeeaa50d7943b18e1436d15683eeee

출처 데이터셋

uspto-grants-2011_07

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US07977358B2