4-(1-Pyrrolidinyl)piperidine → [5-Cyclopropyl-3-pyridin-4-yl-1-(3-trifluoromethoxy-phenyl)-1H-pyrazol-4-yl]-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone

HRID 1011969

반응식

HRID 1011969 반응식
[CH:1]1([C:4]2[N:8]([C:9]3[CH:14]=[CH:13][CH:12]=[C:11]([O:15][C:16]([F:19])([F:18])[F:17])[CH:10]=3)[N:7]=[C:6]([C:20]3[CH:25]=[CH:24][N:23]=[CH:22][CH:21]=3)[C:5]=2[C:26]([OH:28])=O)[CH2:3][CH2:2]1.[N:29]1([CH:34]2[CH2:39][CH2:38][NH:37][CH2:36][CH2:35]2)[CH2:33][CH2:32][CH2:31][CH2:30]1>>[CH:1]1([C:4]2[N:8]([C:9]3[CH:14]=[CH:13][CH:12]=[C:11]([O:15][C:16]([F:18])([F:17])[F:19])[CH:10]=3)[N:7]=[C:6]([C:20]3[CH:21]=[CH:22][N:23]=[CH:24][CH:25]=3)[C:5]=2[C:26]([N:37]2[CH2:38][CH2:39][CH:34]([N:29]3[CH2:33][CH2:32][CH2:31][CH2:30]3)[CH2:35][CH2:36]2)=[O:28])[CH2:2][CH2:3]1

참가 물질

3

반응물 2

HCID 787034-(1-Pyrrolidinyl)piperidineHCID 673156045-Cyclopropyl-3-pyridin-4-yl-1-(3-trifluoromethoxy-phenyl)-1H-pyrazole-4-carboxylic acid

생성물 1

HCID 25206417[5-Cyclopropyl-3-pyridin-4-yl-1-(3-trifluoromethoxy-phenyl)-1H-pyrazol-4-yl]-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone수율 91%

실험 절차

In analogy to the procedure described in Example 160E], 5-cyclopropyl-3-pyridin-4-yl-1-(3-trifluoromethoxy-phenyl)-1H-pyrazole-4-carboxylic acid and 4-(1-pyrrolidinyl)piperidine gave the title compound as a light yellow gum (91%). MS: 526.0 (MH+).

출처 및 근거

ORD 기록
ord-34cf63468b20433baf2fae35dd84a51f
출처 데이터셋
uspto-grants-2011_07
특허 번호
US07977358B2

연결된 노트

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