4-(3,4-Dinitrobenzyl)morpholine → 4-(Morpholinomethyl)benzene-1,2-diamine

HRID 1012092노트

반응식

HRID 1012092 반응식
[N+:1]([C:4]1[CH:5]=[C:6]([CH:14]=[CH:15][C:16]=1[N+:17]([O-])=O)[CH2:7][N:8]1[CH2:13][CH2:12][O:11][CH2:10][CH2:9]1)([O-])=O>CO.[Pd]>[N:8]1([CH2:7][C:6]2[CH:5]=[C:4]([NH2:1])[C:16]([NH2:17])=[CH:15][CH:14]=2)[CH2:13][CH2:12][O:11][CH2:10][CH2:9]1

참가 물질

4

반응물 1

HCID 251933104-(3,4-Dinitrobenzyl)morpholine

생성물 1

HCID 251933094-(Morpholinomethyl)benzene-1,2-diamine수율 113.2%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A mixture of 4-(3,4-dinitro-benzyl)-morpholine (550 mg) and 10% Pd/C (75 mg) in MeOH (10 ml) was shaken under a hydrogen atmosphere at ambient temperature for 4 hours, then filtered through a plug of Celite and reduced in vacuo to give 4-morpholin-4-ylmethyl-benzene-1,2-diamine (483 mg) as the major component of a mixture.

후처리

  1. filtrationfiltered through a plug of Celite

출처 및 근거

ORD 기록
ord-5b99c5fb516745b3a2dcef540ddef763
출처 데이터셋
uspto-grants-2011_07
특허 번호
US07977477B2

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