Ethanolamine → N-(2-hydroxyethyl)-2-iodobenzamide

HRID 1012346노트

반응식

HRID 1012346 반응식
C(=O)([O-])O.[Na+].[NH2:6][CH2:7][CH2:8][OH:9].[I:10][C:11]1[CH:19]=[CH:18][CH:17]=[CH:16][C:12]=1[C:13](Cl)=[O:14]>C(OCC)(=O)C.O>[OH:9][CH2:8][CH2:7][NH:6][C:13](=[O:14])[C:12]1[CH:16]=[CH:17][CH:18]=[CH:19][C:11]=1[I:10]

참가 물질

6

반응물 3

HCID 700EthanolamineHCID 691122-Iodobenzoyl chlorideHCID 516892Sodium Bicarbonate

생성물 1

HCID 2186617N-(2-hydroxyethyl)-2-iodobenzamide수율 87.6%

시약·촉매·용매 2

HCID 962Water용매2회HCID 8857Ethyl Acetate용매2회

실험 절차

To a solution of sodium hydrogen carbonate (3.30 g, 39.7 mmol) and 2-aminoethanol (1.80 ml, 29.8 mmol) in ethyl acetate (25 ml) and water (15 ml) was added dropwise the solution of 2-iodobenzoyl chloride in ethyl acetate prepared above under ice-cooling, and the mixture was stirred at room temperature for 12 hr. Water was added to the reaction mixture and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine and dried over anhydrous sodium sulfate. After filtration, the solvent was evaporated under reduced pressure to give N-(2-hydroxyethyl)-2-iodobenzamide (5.12 g, yield 87.6%).

후처리

  1. customprepared above under ice-
  2. temperaturecooling
  3. extractionthe mixture was extracted with ethyl acetate
  4. washThe organic layer was washed with saturated brine
  5. dry with materialdried over anhydrous sodium sulfate
  6. filtrationAfter filtration
  7. customthe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-5e4c8df6dca14f53aa806e5babad5885
출처 데이터셋
uspto-grants-2011_07
특허 번호
US07977331B1

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