2,3-Dihydro-1,4-benzodioxin-6-carbaldehyde → HCID 178489238, 화합물

HRID 1012922

반응식

HRID 1012922 반응식
[CH3:1][O:2][C:3]1[C:8]2[N:9]=[CH:10][S:11][C:7]=2[CH:6]=[CH:5][CH:4]=1.C(O[C:17](=O)[NH:18][C@H:19]1[CH2:24][CH2:23][C@H:22]([C:25](=[O:30])N(OC)C)[CH2:21][CH2:20]1)(C)(C)C.[O:32]1[C:37]2[CH:38]=[CH:39][C:40](C=O)=[CH:41][C:36]=2[O:35][CH2:34][CH2:33]1>>[O:32]1[C:37]2[CH:38]=[CH:39][C:40]([CH2:17][NH:18][C@H:19]3[CH2:20][CH2:21][C@H:22]([C:25]([C:10]4[S:11][C:7]5[CH:6]=[CH:5][CH:4]=[C:3]([O:2][CH3:1])[C:8]=5[N:9]=4)=[O:30])[CH2:23][CH2:24]3)=[CH:41][C:36]=2[O:35][CH2:34][CH2:33]1

참가 물질

4

반응물 3

HCID 2481272,3-Dihydro-1,4-benzodioxin-6-carbaldehydeHCID 126318584-Methoxy-1,3-benzothiazoleHCID 178502731HCID 178502731, 화합물

생성물 1

HCID 178489238HCID 178489238, 화합물

실험 절차

Using 4-methoxy-benzothiazole (5 mmol), [trans-4-(methoxy-methyl-carbamoyl)-cyclohexyl]-carbamic acid tert-butyl ester (2.5 mmol) and 2,3-dihydro-benzo[1,4]dioxine-6-carbaldehyde (0.3 mmol) according to the same protocol as that described for example 1, steps 1.a to 1.c, the title compound was obtained as a off-white solid (41 mg).

출처 및 근거

ORD 기록
ord-c37facaf906446528f955f588c4ba5d6
출처 데이터셋
uspto-grants-2011_07
특허 번호
US07981886B2

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