2-(3-(2-Phenyl-1,3-dioxolan-2-yl)propyl)isoindoline-1,3-dione → HCID 23123945, 화합물

HRID 1013121노트

반응식

HRID 1013121 반응식
[C:1]1([C:7]2([CH2:12][CH2:13][CH2:14][N:15]3C(=O)C4C(=CC=CC=4)C3=O)[O:11][CH2:10][CH2:9][O:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>CN.CO>[C:1]1([C:7]2([CH2:12][CH2:13][CH2:14][NH2:15])[O:11][CH2:10][CH2:9][O:8]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

4

반응물 1

HCID 574477532-(3-(2-Phenyl-1,3-dioxolan-2-yl)propyl)isoindoline-1,3-dione

생성물 1

HCID 23123945HCID 23123945, 화합물수율 47%

시약·촉매·용매 2

HCID 887Methanol용매HCID 6329Methylamine용매

반응 조건

온도
50 °C

실험 절차

Dissolve 2-[3-(2-phenyl-[1,3]dioxolan-2-yl)-propyl]-isoindole-1,3-dione (38 g, 112.91 mmol) in 2 M methylamine solution in methanol (300 mL) and heat in a sealed tube for 3 h at 50° C. Cool the solution to RT, concentrate and purify (silica gel chromatography, eluting with 25:75 DCM:2 M ammonia in methanol) to give the title compound as an oil (11 g, 47%).

후처리

  1. temperatureCool the solution to RT
  2. concentrationconcentrate
  3. custompurify
  4. wash(silica gel chromatography, eluting with 25:75 DCM:2 M ammonia in methanol)

출처 및 근거

ORD 기록
ord-fee58fb23f764427b57a61836060b4de
출처 데이터셋
uspto-grants-2011_07
특허 번호
US07981882B2

반응 노트

불러오는 중…