HCID 67205102, 화합물 → 1-(1-Phenyl-ethyl)-4-thiophen-2-yl-pyrrolidine-3-carboxylic acid

HRID 1013415노트

반응식

HRID 1013415 반응식
C([O:3][C:4]([CH:6]1[CH:10]([C:11]2[S:12][CH:13]=[CH:14][CH:15]=2)[CH2:9][N:8]([CH:16]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH3:17])[CH2:7]1)=[O:5])C.C1NCC2C1CC1C(C#N)=CSC=12>>[C:18]1([CH:16]([N:8]2[CH2:9][CH:10]([C:11]3[S:12][CH:13]=[CH:14][CH:15]=3)[CH:6]([C:4]([OH:5])=[O:3])[CH2:7]2)[CH3:17])[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

참가 물질

3

반응물 2

HCID 67205102HCID 67205102, 화합물HCID 683017591,2,3,3a,7,7a-Hexahydro-4-thia-2-aza-cyclopenta[alpha]pentalene-6-carbonitrile

생성물 1

HCID 672065311-(1-Phenyl-ethyl)-4-thiophen-2-yl-pyrrolidine-3-carboxylic acid

실험 절차

The product from step b), diastereomer 1 (5.8 g, 0.019 mol) was treated by the method outlined in Example 34, step c) to afford the subtitle compound that was used in the next step without further purification. MS calculated for C17H19NO2S +H: 302, observed: 302.

출처 및 근거

ORD 기록
ord-582bd42a8276480dab9616b25110e0c3
출처 데이터셋
uspto-grants-2011_07
특허 번호
US07981919B2

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