Diphenyl Ether → Methoxy-1H-[1,5]naphthyridin-4-one

HRID 1013633노트

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HRID 1013633 반응식
CO[C:3]1[CH:4]=[C:5]([NH:9][CH:10]=[C:11]2[C:16](=[O:17])OC(C)(C)OC2=O)[CH:6]=[N:7][CH:8]=1.[C:21]1([O:27]C2C=CC=CC=2)C=CC=CC=1>CCCCCC>[CH3:21][O:27][N:9]1[C:5]2[C:6](=[N:7][CH:8]=[CH:3][CH:4]=2)[C:16](=[O:17])[CH:11]=[CH:10]1

참가 물질

4

반응물 2

HCID 7583Diphenyl EtherHCID 673177565-[(5-Methoxy-pyridin-3-ylamino)-methylene]-2,2-dimethyl-[1,3]dioxane-4,6-dione

생성물 1

HCID 86628663Methoxy-1H-[1,5]naphthyridin-4-one

시약·촉매·용매 1

HCID 8058Hexane용매2회

반응 조건

온도
245 °C

실험 절차

A two-necked RBF equipped with an air condenser was charged with 5-[(5-Methoxy-pyridin-3-ylamino)-methylene]-2,2-dimethyl-[1,3]dioxane-4,6-dione (18 g) and diphenyl ether (180 mL). The reaction mixture was heated at 240-250° C. for 5 min under N2 atmosphere after which it was cooled to RT, diluted with hexane and filtered to obtain a dark solid. The crude product was refluxed in hexane for 30 min and filtered to obtain product as a brown solid.

후처리

  1. customA two-necked RBF equipped with an air condenser
  2. temperaturewas cooled to RT
  3. filtrationfiltered
  4. customto obtain a dark solid
  5. filtrationfiltered
  6. customto obtain product as a brown solid

출처 및 근거

ORD 기록
ord-7919f8dddc4f4cc3afc6bd2113cf0c54
출처 데이터셋
uspto-grants-2011_07
특허 번호
US07981891B2

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