Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1013779생성일: 2026년 10월 25일
Dimethyl Sulfoxide → N-(4-(7-(benzyloxy)-1,5-naphthyridin-4-yloxy)phenyl)-4-(4-chlorophenyl)phthalazin-1-amine
https://huagongshe.com/reaction/1013779
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Dimethyl Sulfoxide | HCID 679 | — |
| 반응물 | Cesium carbonate | HCID 10796 | — |
| 반응물 | 3-(Benzyloxy)-8-chloro-1,5-naphthyridine | HCID 67316944 | — |
| 반응물 | 4-(4-(4-Chlorophenyl)phthalazin-1-ylamino)phenol hydrochloride | HCID 136381728 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | N-(4-(7-(benzyloxy)-1,5-naphthyridin-4-yloxy)phenyl)-4-(4-chlorophenyl)phthalazin-1-amine | HCID 67316920 | — |
반응 단계
A pyrex reaction tube was charged with 4-(4-(4-chlorophenyl)phthalazin-1-ylamino)phenol hydrochloride (344 mg, 894 μmol), 3-(benzyloxy)-8-chloro-1,5-naphthyridine (220 mg, 813 μmol), cesium carbonate (662 mg, 2032 μmol) and 4.1 mL DMSO. The tube was sealed and the mixture was heated at 100° C. for 4 h. Water was added and the resulting precipitate was filtered, washed with water and dried. The crude material was purified by silica gel chromatography, 90/10/1 DCM/MeOH/NH4OH in DCM to provide N-(4-(7-(benzyloxy)-1,5-naphthyridin-4-yloxy)phenyl)-4-(4-chlorophenyl)phthalazin-1-amine. MS: [M+H]=583.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US07981891B2 |
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| 출처 데이터셋 | uspto-grants-2011_07 |
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| ORD ID | ord-97a4dae240594db4805432641c4ea0ef |
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| 출처 메모 | uspto-grants-2011_07 |
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