Hydrazine → 2-Amino-4-hydroxy-6-hydrazinopyrimidine
반응식
[NH2:1][C:2]1[NH:7][C:6](=[O:8])[CH:5]=[C:4](Cl)[N:3]=1.[NH2:10][NH2:11]>O>[NH2:1][C:2]1[NH:7][C:6](=[O:8])[CH:5]=[C:4]([NH:10][NH2:11])[N:3]=1참가 물질
4
실험 절차
A stirred suspension of 15.0 g (103 mmol) of 1 in 250 mL water was added 12 g (375 mmol) of anhydrous hydrazine, and the mixture was heated at reflux for 3 h. The resulting clear solution was cooled, and the precipitate which separated was collected by filtration, washed with water followed by ethanol and dried to give 6.6 g (46%) of white solid. mp decomposes at 313° C. (Literature mp 314-315° C., see Taylor, E. C; Cocuzza, J. A. Synthesis and Properties of 7-Azaxanthopterin. J. Org Chem. 1979, 44, 1125-1128.).
후처리
- temperaturethe mixture was heated
- temperatureat reflux for 3 h
- temperatureThe resulting clear solution was cooled
- customthe precipitate which separated
- filtrationwas collected by filtration
- washwashed with water
- customdried
출처 및 근거
- ORD 기록
- ord-eab550c2403147118249c25e4b216128
- 출처 데이터셋
- uspto-grants-2011_07
- 특허 번호
- US07982035B2
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