Benzyl Alcohol → 4-Benzyloxy-3-chloronitrobenzene

HRID 1013913

반응식

HRID 1013913 반응식
[OH-].[K+].[Cl:3][C:4]1[CH:5]=[C:6]([N+:11]([O-:13])=[O:12])[CH:7]=[CH:8][C:9]=1F.[CH2:14]([OH:21])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>C(#N)C>[CH2:14]([O:21][C:9]1[CH:8]=[CH:7][C:6]([N+:11]([O-:13])=[O:12])=[CH:5][C:4]=1[Cl:3])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

참가 물질

5

반응물 3

HCID 244Benzyl AlcoholHCID 14797Potassium HydroxideHCID 676882-Chloro-1-fluoro-4-nitrobenzene

생성물 1

HCID 3085094-Benzyloxy-3-chloronitrobenzene수율 75.4%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

A 15.43 g (0.275 moles) portion of solid (pellets) potassium hydroxide was added to a solution of 43.89 g (0.25 moles) of 3-chloro-4-fluoro nitrobenzene and 32.34 ml (33.79 grams, 0.373 moles) of benzyl alcohol in 220 ml of acetonitrile. The reaction was vigorously stirred with a mechanical stirrer overnight. The resulting solid was filtered. Concentration of the filtrate gave a second crop, which was also filtered. On standing more solid came out of this filtrate. This mixture was treated with ether, and the solid filtered. All solids were washed thoroughly with water, and combined to give 49.71 g of the title compound.

후처리

  1. filtrationThe resulting solid was filtered
  2. customConcentration of the filtrate gave a second crop, which
  3. filtrationwas also filtered
  4. additionThis mixture was treated with ether
  5. filtrationthe solid filtered
  6. washAll solids were washed thoroughly with water

출처 및 근거

ORD 기록
ord-58bfc3ed250047fbb65e5723ee1d678e
출처 데이터셋
uspto-grants-2011_07
특허 번호
US07982043B2

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