Chloroacetyl chloride → HCID 246995, 화합물

HRID 1014225노트

반응식

HRID 1014225 반응식
[CH3:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10].C(N(CC)CC)C.[Cl:19][CH2:20][C:21](Cl)=[O:22]>C1COCC1>[Cl:19][CH2:20][C:21]([NH:6][C:5]1[CH:7]=[CH:8][C:2]([CH3:1])=[C:3]([N+:9]([O-:11])=[O:10])[CH:4]=1)=[O:22]

참가 물질

5

반응물 3

HCID 6577Chloroacetyl chlorideHCID 83904-Methyl-3-nitroanilineHCID 8471Triethylamine

생성물 1

HCID 246995HCID 246995, 화합물수율 90%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A solution of 4-methyl-3-nitroaniline (1.0 g, 6.58 mmol, Lancaster), triethylamine (2.00 g, 19.7 mmol, Aldrich), and chloroacetyl chloride (0.96 g, 8.55 mmol) in THF (50 mL) was stirred overnight at rt. The reaction was washed with 1M HCl (50 mL), concentrated by rotary evaporation, and placed under high vacuum to give 2-chloro-N-(4-methyl-3-nitrophenyl)acetamide (1.35 g, 90%). ESIMS (M+H)+=229.

후처리

  1. washThe reaction was washed with 1M HCl (50 mL)
  2. concentrationconcentrated by rotary evaporation

출처 및 근거

ORD 기록
ord-aea5b5ac0427433db5c7d298da7f3c6d
출처 데이터셋
uspto-grants-2011_07
특허 번호
US07981903B2

반응 노트

불러오는 중…