7-Methoxy-1,2,3,4-tetrahydroisoquinolin-6-ol → (6-Chloro-pyrazolo[1,5-a]pyrimidin-2-yl)-(6-hydroxy-7-methoxy-3,4-dihydro-1H-isoquinolin-2-yl)-methanone

HRID 1015096

반응식

HRID 1015096 반응식
[Cl:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([OH:13])=O)[CH:10]=2)[CH:7]=1.[CH3:14][O:15][C:16]1[CH:25]=[C:24]2[C:19]([CH2:20][CH2:21][NH:22][CH2:23]2)=[CH:18][C:17]=1[OH:26]>>[Cl:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([N:22]3[CH2:21][CH2:20][C:19]4[C:24](=[CH:25][C:16]([O:15][CH3:14])=[C:17]([OH:26])[CH:18]=4)[CH2:23]3)=[O:13])[CH:10]=2)[CH:7]=1

참가 물질

3

반응물 2

HCID 4172897-Methoxy-1,2,3,4-tetrahydroisoquinolin-6-olHCID 336956786-Chloropyrazolo[1,5-A]pyrimidine-2-carboxylic acid

생성물 1

HCID 24810083(6-Chloro-pyrazolo[1,5-a]pyrimidin-2-yl)-(6-hydroxy-7-methoxy-3,4-dihydro-1H-isoquinolin-2-yl)-methanone

실험 절차

In close analogy to the procedure described in Example 1, 6-chloro-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid is reacted with 7-methoxy-1,2,3,4-tetrahydro-isoquinolin-6-ol to provide the title compound as a solid.

출처 및 근거

ORD 기록
ord-d01a49c1316b43a2bc1d71981f29967e
출처 데이터셋
uspto-grants-2011_07
특허 번호
US07985753B2

연결된 노트

불러오는 중…