6-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acid → HCID 24810413, 화합물

HRID 1015112노트

반응식

HRID 1015112 반응식
[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([OH:13])=O)[CH:10]=2)[CH:7]=1.[F:14][C:15]1[CH:16]=[CH:17][CH:18]=[C:19]2[C:24]=1[CH:23]([CH3:25])[NH:22][CH2:21][CH2:20]2>>[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([N:22]3[CH2:21][CH2:20][C:19]4[C:24](=[C:15]([F:14])[CH:16]=[CH:17][CH:18]=4)[CH:23]3[CH3:25])=[O:13])[CH:10]=2)[CH:7]=1

참가 물질

3

반응물 2

HCID 7719386-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acidHCID 535343961176414-86-0

생성물 1

HCID 24810413HCID 24810413, 화합물

실험 절차

In close analogy to the procedure described in Example 1, 6-bromo-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid is reacted with 8-fluoro-1-methyl-1,2,3,4-tetrahydro-isoquinoline to provide the title compound in moderate yield.

출처 및 근거

ORD 기록
ord-133c83098447442993cd6d56069a556e
출처 데이터셋
uspto-grants-2011_07
특허 번호
US07985753B2

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