6-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acid → HCID 24810787, 화합물

반응식

[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([OH:13])=O)[CH:10]=2)[CH:7]=1.[N+:14]([C:17]1[CH:26]=[CH:25][CH:24]=[C:23]2[C:18]=1[CH2:19][CH2:20][NH:21][CH2:22]2)([O-:16])=[O:15]>>[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([N:21]3[CH2:20][CH2:19][C:18]4[C:23](=[CH:24][CH:25]=[CH:26][C:17]=4[N+:14]([O-:16])=[O:15])[CH2:22]3)=[O:13])[CH:10]=2)[CH:7]=1

참가 물질

반응물 2

HCID 7719386-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acid

HCID 113799065-Nitro-1,2,3,4-tetrahydroisoquinoline

생성물 1

HCID 24810787HCID 24810787, 화합물

실험 절차

In close analogy to the procedure described in Example 1, 6-bromo-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid is reacted with 5-Nitro-1,2,3,4-tetrahydro-isoquinoline to provide the title compound in moderate yield.

출처 및 근거

ORD 기록: ord-81d808274ac84bccb03845e8281a66b1
출처 데이터셋: uspto-grants-2011_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07985753B2

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