6-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acid → HCID 58416484, 화합물

반응식

[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([OH:13])=O)[CH:10]=2)[CH:7]=1.[Cl:14][C:15]1[CH:16]=[C:17]2[C:22](=[CH:23][C:24]=1[Cl:25])[CH:21]([CH3:26])[NH:20][CH2:19][CH2:18]2>>[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([N:20]3[CH2:19][CH2:18][C:17]4[C:22](=[CH:23][C:24]([Cl:25])=[C:15]([Cl:14])[CH:16]=4)[CH:21]3[CH3:26])=[O:13])[CH:10]=2)[CH:7]=1

참가 물질

반응물 2

HCID 7719386-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acid

HCID 196102886,7-Dichloro-1,2,3,4-tetrahydro-1-methylisoquinoline

생성물 1

HCID 58416484HCID 58416484, 화합물

실험 절차

In close analogy to the procedure described in Example 1, 6-bromo-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid is reacted with 6,7-dichloro-1-methyl-1,2,3,4-tetrahydro-isoquinoline to provide the title compound in moderate yield.

출처 및 근거

ORD 기록: ord-d7e11910107f4a6796830c2fbfbc4550
출처 데이터셋: uspto-grants-2011_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07985753B2

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