Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dimethylformamide → Fmoc-leucine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | Thionyl Chloride | HCID 24386 | — |
| 반응물 | Glycine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-(2-methylpropyl)- | HCID 11727923 | — |
| 용매 | Chlorine | HCID 24526 | — |
| 생성물 | Fmoc-leucine | HCID 1549133 | — |
반응 단계
FMOC-Leu*-Cl was prepared by dissolving FMOC-N-isobutylglycine (150 mg, 0.42 mmol) in CH2 Cl2 (2.8 mL), and adding thionyl chloride (309 μL, 4.2 mmol) and 3 μL DMF (0.04 mmol). The reaction mixture was stirred for 5 hours and concentrated in vacuo, repeatedly dissolving in CH2 Cl2 (3××) to provide FMOC-Leu*-Cl as a colorless oil (146 mg, 92%): IR (cm−1) -1804, 1720, 1715. FMOC-Phe*-Cl was similarly prepared.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07094758B2 |
| 출처 데이터셋 | uspto-grants-2006_08 |
| ORD ID | ord-6f32846c3f30491a999c9981e0eac7a6 |
| 출처 메모 | uspto-grants-2006_08 |