Potassium Carbonate → Alfa-oxo-1H-pyrrolo-[2,3B]pyridine-3-acetic acid monopotassium salt

HRID 1016488노트

반응식

HRID 1016488 반응식
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][N:8]=2)[C:3]([C:10](=[O:15])[C:11]([O:13]C)=[O:12])=[CH:2]1.C([O-])([O-])=O.[K+:20].[K+]>CO.O>[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][N:8]=2)[C:3]([C:10](=[O:15])[C:11]([O-:13])=[O:12])=[CH:2]1.[K+:20]

참가 물질

5

반응물 2

HCID 11430Potassium CarbonateHCID 6028556Methyl 7-azaindole-3-glyoxylate

생성물 1

HCID 23721194Alfa-oxo-1H-pyrrolo-[2,3B]pyridine-3-acetic acid monopotassium salt수율 90.4%

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

Compound 2a (43 g, 0.21 mol) and K2CO3 (56.9 g, 0.41 mol) were dissolved in MeOH (200 ml) and H2O (200 ml). After 8 hours, product 3a precipitated out from the solution. Filtration afforded 43 g of compound 3a as a white solid in 90.4% yield.

후처리

  1. customproduct 3a precipitated out from the solution
  2. filtrationFiltration

출처 및 근거

ORD 기록
ord-127d1864ea434f1a9a795bb9a1570d46
출처 데이터셋
uspto-grants-2002_11
특허 번호
US06476034B2

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