Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Chloromethyl Methyl Ether → 3-Methoxy-4-methoxymethoxy-benzonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Chloromethyl Methyl Ether | HCID 7864 | — |
| 반응물 | 4-Hydroxy-3-methoxybenzonitrile | HCID 78135 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 3-Methoxy-4-methoxymethoxy-benzonitrile | HCID 22258333 | 80% |
반응 단계
A solution of 4-hydroxy-3-methoxy-benzonitrile (11, 1.5 g, 10 mmol) and diisopropylethylamine (2.7 mL, 15 mmol) in CH2Cl2 (50 mL) was treated with chloromethylmethylether (0.92 mL, 12 mmol) and stirred for 3 h. After diluted with CH2Cl2, the mixture was washed with H2O, dried over MgSO4 and concentrated in vacuo. The residue was purified by flash column chromatography over silica gel using EtOAc:Hex (1:2) as eluant to give 12 as white solid (1.54 g, 80%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06476076B1 |
| 출처 데이터셋 | uspto-grants-2002_11 |
| ORD ID | ord-de16a529e10344f6a3f98e7a744a07a7 |
| 출처 메모 | uspto-grants-2002_11 |