Triethylamine → 4'-[[(2,5-Dioxo-1-pyrrolidinyl)oxy]carbonyl][1,1'-biphenyl]-4-carbonyl chloride

HRID 1016665

반응식

HRID 1016665 반응식
[C:1]1([C:10]2[CH:15]=[CH:14][C:13]([C:16](Cl)=[O:17])=[CH:12][CH:11]=2)[CH:6]=[CH:5][C:4]([C:7]([Cl:9])=[O:8])=[CH:3][CH:2]=1.[OH:19][N:20]1[C:24](=[O:25])[CH2:23][CH2:22][C:21]1=[O:26].C(N(CC)CC)C>C1COCC1>[O:26]=[C:21]1[CH2:22][CH2:23][C:24](=[O:25])[N:20]1[O:19][C:16]([C:13]1[CH:14]=[CH:15][C:10]([C:1]2[CH:6]=[CH:5][C:4]([C:7]([Cl:9])=[O:8])=[CH:3][CH:2]=2)=[CH:11][CH:12]=1)=[O:17]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 75374[1,1'-Biphenyl]-4,4'-dicarbonyl dichlorideHCID 80170N-Hydroxysuccinimide

생성물 1

HCID 184075094'-[[(2,5-Dioxo-1-pyrrolidinyl)oxy]carbonyl][1,1'-biphenyl]-4-carbonyl chloride수율 93.2%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A solution of 1.67 g (6.0 mmol) of 11 in 65 mL of dry THF was treated with 710 mg (6.17 mmol) of N-hydroxysuccinimide, followed by 0.835 mL (6.0 mmol) of triethylamine. The reaction was stirred at room temperature for 2 hours after which time it was filtered to remove triethylamine HCl. The filtrate was concentrated at reduced pressure to yield 2.0 g (93%) of 12 as a pale yellow solid.

후처리

  1. filtrationwas filtered
  2. customto remove triethylamine HCl
  3. concentrationThe filtrate was concentrated at reduced pressure

출처 및 근거

ORD 기록
ord-738c6229ccb84d8488f1e38389f9b3cb
출처 데이터셋
uspto-grants-2002_11
특허 번호
US06476199B1

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