참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 2-(4-tert-Butylphenoxy)ethanol | HCID 12841 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | Ammonium Chloride | HCID 25517 | — |
| 반응물 | 4-Chloro-3-methoxy-2-methylpyridine | HCID 10583046 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 생성물 | 2-Methyl-3-methoxy-4-[2-(4-tert-butylphenoxy)ethoxy]pyridine | HCID 19694023 | — |
반응 단계
A mixture of 1.57 g (10 mmol) of 2-methyl-3-methoxy-4-chloropyridine, 2.52 g (13 mmol) of 2-(4-tert-butylphenoxy)ethanol and 15 ml of DMSO is added dropwise at 25° C. to 0.36 g (12 mmol) of NaH (80% strength) in 25 ml of DMSO. The mixture is then stirred at 60° C. for 5 hours. For working up, saturated ammonium chloride solution is added at 20° to 25° C. and the mixture is extracted with ethyl acetate. The reaction product is purified by chromatography (SiO2 ; EtOAc). Yield: 2.63 g (74.9%); m.p.: 84° to 87° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05723450 |
|---|
| 출처 데이터셋 | uspto-grants-1998_03 |
|---|
| ORD ID | ord-81b10c28bd9c47d5984b354d59da9d19 |
|---|
| 출처 메모 | uspto-grants-1998_03 |
|---|
