Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl vinyl ketone → (2R)-1-[3,5-bis(trifluoromethyl)-benzoyl]-2-(1H-indol-3-ylmethyl)-4-(3-butanon-1-yl)piperazine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl vinyl ketone | HCID 6570 | — |
| 반응물 | (2R)-1-[3,5-bis(trifluoromethyl)benzoyl]-2-(1H-indol-3-ylmethyl)-4-(4-pentanon-1-yl)piperazine | HCID 58681862 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | (2R)-1-[3,5-bis(trifluoromethyl)-benzoyl]-2-(1H-indol-3-ylmethyl)-4-(3-butanon-1-yl)piperazine | HCID 58681860 | — |
반응 단계
To a solution of (2R)-1-[3,5-bis(trifluoromethyl)benzoyl]-2-(1H-indol-3-ylmethyl)-4-(4-pentanon-1-yl)piperazine (1.37 g) in toluene (15 mL) was added drop-wise methyl vinyl ketone (0.3 g). After 2.5 h at room temperature the solution was concentrated to afford crude (2R)-1-[3,5-bis(trifluoromethyl)-benzoyl]-2-(1H-indol-3-ylmethyl)-4-(3-butanon-1-yl)piperazine which was used as such. Rf 0.55 (CH2Cl2/MeOH 95/5).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07094779B2 |
| 출처 데이터셋 | uspto-grants-2006_08 |
| ORD ID | ord-755c0c4338ec42bd89c9aaaf59b8e5e7 |
| 출처 메모 | uspto-grants-2006_08 |