8-Methylquinoline-5-carboxylic acid → 8-Methyl-1,2,3,4-tetrahydroquinoline-5-carboxylic acid

HRID 1017130노트

반응식

HRID 1017130 반응식
[CH3:1][C:2]1[C:11]2[N:10]=[CH:9][CH:8]=[CH:7][C:6]=2[C:5]([C:12]([OH:14])=[O:13])=[CH:4][CH:3]=1.[H][H]>[Pd].C(O)C>[CH3:1][C:2]1[C:11]2[NH:10][CH2:9][CH2:8][CH2:7][C:6]=2[C:5]([C:12]([OH:14])=[O:13])=[CH:4][CH:3]=1

참가 물질

5

반응물 2

HCID 129507838-Methylquinoline-5-carboxylic acidHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 139517338-Methyl-1,2,3,4-tetrahydroquinoline-5-carboxylic acid

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

0.1 mol of 8-methylquinoline-5-carboxylic acid was suspended in 1.5 1 of ethanol and admixed with 10.0 g of palladium on activated carbon (5%). In an autoclave, the mixture was reduced at 50° C. with hydrogen (1 bar) over a period of 48 hours (HPLC monitoring). The reaction mixture was subsequently filtered, the filter cake was washed with ethanol and the combined organic filtrates were concentrated.

후처리

  1. filtrationThe reaction mixture was subsequently filtered
  2. washthe filter cake was washed with ethanol
  3. concentrationthe combined organic filtrates were concentrated

출처 및 근거

ORD 기록
ord-ff2acbc3e664438e90c8f8519055686b
출처 데이터셋
uspto-grants-2002_11
특허 번호
US06479436B1

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