tert-butyl (2S)-2-[[4-(dihexylamino)-1,1-dioxo-1,2,5-thiadiazol-3-yl]amino]-3-(4-hydroxyphenyl)propanoate → HCID 178444782, 화합물

HRID 1017506

반응식

HRID 1017506 반응식
C([O:5][C:6](=[O:37])[C@H:7]([CH2:29][C:30]1[CH:35]=[CH:34][C:33]([OH:36])=[CH:32][CH:31]=1)[NH:8][C:9]1[C:13]([N:14]([CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20])=[N:12][S:11](=[O:28])(=[O:27])[N:10]=1)(C)(C)C>C(O)=O>[CH2:15]([N:14]([C:13]1[C:9]([NH:8][C@H:7]([C:6]([OH:37])=[O:5])[CH2:29][C:30]2[CH:35]=[CH:34][C:33]([OH:36])=[CH:32][CH:31]=2)=[N:10][S:11](=[O:27])(=[O:28])[N:12]=1)[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])[CH2:16][CH2:17][CH2:18][CH2:19][CH3:20]

참가 물질

3

반응물 1

HCID 178444783tert-butyl (2S)-2-[[4-(dihexylamino)-1,1-dioxo-1,2,5-thiadiazol-3-yl]amino]-3-(4-hydroxyphenyl)propanoate

생성물 1

HCID 178444782HCID 178444782, 화합물수율 98.6%

시약·촉매·용매 1

HCID 284Formic Acid용매

실험 절차

N-(4-(N,N-Di-n-hexylamino)-1,1-dioxo-1,2,5-thiadiazol-3-yl)-L-tyrosine tert-butyl ester (100 mg, 0.19 mmol) was dissolved in formic acid and the mixture stirred at room temperature for 36 hrs. Excess formic acid was removed under reduced pressure to yield N-(4-(N,N-Di-n-hexylamino)-1,1-dioxo-1,2,5-thiadiazol-3-yl)-L-tyrosine as a white solid (90 mg, 98%). Anal. Calc'd for C23H36N4O5S: C, 57.48; H, 7.55; N, 11.66. Found: C, 57.04; H, 7.23; N, 11.38.

후처리

  1. customExcess formic acid was removed under reduced pressure

출처 및 근거

ORD 기록
ord-ad6abf92c21a464ebc73a05d4bd581b5
출처 데이터셋
uspto-grants-2002_11
특허 번호
US06479492B1

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