2,5-Dimethoxybenzaldehyde → 2-(2,5-dimethoxyphenyl)-3H-quinazolin-4-one

반응식

[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[NH:18][C:17](=[O:19])[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[N:10]=1.[CH3:20][O:21]C1C=CC(OC)=CC=1C=O>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([O:21][CH3:20])=[CH:5][C:4]=1[C:9]1[NH:18][C:17](=[O:19])[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[N:10]=1

참가 물질

반응물 2

HCID 667262,5-Dimethoxybenzaldehyde

HCID 1354360052-(2-methoxyphenyl)-3H-quinazolin-4-one

생성물 1

HCID 1354636732-(2,5-dimethoxyphenyl)-3H-quinazolin-4-one수율 88.6%

실험 절차

According to the preparation of 42, 2,5-dimethoxybenzaldehyde (38) (1.2 g, 7.3 mmol) was used to afford 47 (1.8 g, 88.6%) as pale yellow prism crystals.

출처 및 근거

ORD 기록: ord-f1076521f01845c3aca4038d0716f815
출처 데이터셋: uspto-grants-2002_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06479499B1

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