Anthranilamide → 2-(3-methoxyphenyl)quinazolin-4(3H)-one

HRID 1017535노트

반응식

HRID 1017535 반응식
[NH2:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5].[CH3:11][O:12][C:13]1[CH:14]=[C:15]([CH:18]=[CH:19][CH:20]=1)[CH:16]=O>CC(N(C)C)=O>[CH3:11][O:12][C:13]1[CH:14]=[C:15]([C:16]2[NH:6][C:4](=[O:5])[C:3]3[C:2](=[CH:10][CH:9]=[CH:8][CH:7]=3)[N:1]=2)[CH:18]=[CH:19][CH:20]=1

참가 물질

4

반응물 2

HCID 6942AnthranilamideHCID 115693-Methoxybenzaldehyde

생성물 1

HCID 1354863992-(3-methoxyphenyl)quinazolin-4(3H)-one수율 16.3%

시약·촉매·용매 1

HCID 31374Dimethylacetamide용매

실험 절차

2-Aminobenzamide (30) (1.0 g, 7.3 mmol) and 3-methoxybenzaldehyde (34) (1.0 g, 7.3 mmol) were heated with stirring in DMAC (20 ml) at 80° C. for 2 h and then poured into ice water (200 ml). The precipitate was collected, washed with water, then dried and purified by column chromatography (silica gel-ethyl acetate/n-hexane) to afford 43 (0.3 g, 15.0%) and 61 (1.4 g, 75.2%) as pale yellow powder. Yield, mp, and spectral data are given in Table 1.

후처리

  1. customThe precipitate was collected
  2. washwashed with water
  3. customdried
  4. custompurified by column chromatography (silica gel-ethyl acetate/n-hexane)

출처 및 근거

ORD 기록
ord-e7836cef411d4e559316193769bcd575
출처 데이터셋
uspto-grants-2002_11
특허 번호
US06479499B1

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