Ethyl 4-chlorobutyrate → 4-Ethoxycarbonylpropoxy-2-phenylquinazoline

HRID 1017538노트

반응식

HRID 1017538 반응식
[CH3:1][O:2][C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[N:6]=[C:5]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[N:4]=1.ClC[CH2:21][CH2:22][C:23]([O:25][CH2:26][CH3:27])=[O:24]>>[CH2:26]([O:25][C:23]([CH2:22][CH2:21][CH2:1][O:2][C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[N:6]=[C:5]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[N:4]=1)=[O:24])[CH3:27]

참가 물질

3

반응물 2

HCID 18474Ethyl 4-chlorobutyrateHCID 6168674-Methoxy-2-phenylquinazoline

생성물 1

HCID 701595634-Ethoxycarbonylpropoxy-2-phenylquinazoline수율 88.6%

실험 절차

According to the preparation of 69, ethyl 4-chlorobutyrate (1.36 g, 9.00 mmol) was used to yield 72 (1.34 g, 88.6%) as colorless powder.

출처 및 근거

ORD 기록
ord-61f78afca3474728bae7711c964eea4c
출처 데이터셋
uspto-grants-2002_11
특허 번호
US06479499B1

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