Hydroquinone → 2,5-Dimethyl-4-(2-methoxycarbonyl-ethyl-amino)-1-iodo-benzene

HRID 1017794노트

반응식

HRID 1017794 반응식
[CH3:1][C:2]1[CH:8]=[C:7]([I:9])[C:6]([CH3:10])=[CH:5][C:3]=1[NH2:4].[C:11]([O:15][CH3:16])(=[O:14])[CH:12]=[CH2:13].[OH-].C([N+](C)(C)C)C1C=CC=CC=1.C1(C=CC(O)=CC=1)O>>[CH3:10][C:6]1[CH:5]=[C:3]([NH:4][CH2:13][CH2:12][C:11]([O:15][CH3:16])=[O:14])[C:2]([CH3:1])=[CH:8][C:7]=1[I:9]

참가 물질

5

반응물 4

HCID 785HydroquinoneHCID 7294Methyl AcrylateHCID 66854Benzyltrimethylammonium hydroxideHCID 4770984(4-Iodo-2,5-Dimethylphenyl)Amine

생성물 1

HCID 184051642,5-Dimethyl-4-(2-methoxycarbonyl-ethyl-amino)-1-iodo-benzene

실험 절차

15.0 g (0.061 mol) of 2,5-dimethyl-4-iodo-aniline, 55 ml of (0.611 mol) of methyl acrylate, 6 ml of benzyltrimethyl ammonium hydroxide and 0.3 g (3 mmol) of hydroquinone are refluxed for 11 days. Then the excess acrylate is distilled off and the residue is chromatographed on silica gel, eluting with methylene chloride.

후처리

  1. distillationThen the excess acrylate is distilled off
  2. customthe residue is chromatographed on silica gel
  3. washeluting with methylene chloride

출처 및 근거

ORD 기록
ord-65e182c3e64e4a9287ee1088b3c7c16d
출처 데이터셋
uspto-grants-2002_11
특허 번호
US06479524B1

반응 노트

불러오는 중…