Acetic acid, 2-(triphenylphosphoranylidene)-, ethyl ester → HCID 54370741, 화합물

HRID 1017994노트

반응식

HRID 1017994 반응식
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([CH:10]=O)=[N:8][CH:9]=1)([O-:3])=[O:2].[C:12]([CH:17]=P(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)([O:14][CH2:15][CH3:16])=[O:13]>C1(C)C=CC=CC=1>[CH2:15]([O:14][C:12](=[O:13])[CH:17]=[CH:10][C:7]1[CH:6]=[CH:5][C:4]([N+:1]([O-:3])=[O:2])=[CH:9][N:8]=1)[CH3:16]

참가 물질

4

반응물 2

HCID 70670Acetic acid, 2-(triphenylphosphoranylidene)-, ethyl esterHCID 151455015-Nitropyridine-2-carbaldehyde

생성물 1

HCID 54370741HCID 54370741, 화합물

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

A mixture of 5-nitro-2-pyridinecarbaldehyde (2.85 g prepared according the procedure described in J. Med. Chem. 1992, 35, 3675) and (carbethoxymethylene)triphenylphosphorane (6.0 g) in dry toluene (120 ml) under nitrogen was stirred and heated at reflux for 6 hours. After standing at room temperature overnight the reaction mixture was evaporated. The residue was subjected to flash chromatography on silica gel eluting with dichloromethane to give the title compound (0.8 g) as a yellow solid.

후처리

  1. customprepared
  2. temperatureheated
  3. temperatureat reflux for 6 hours
  4. customthe reaction mixture was evaporated

출처 및 근거

ORD 기록
ord-c3dae748d3bf43a6b4d078efe8ca413c
출처 데이터셋
uspto-grants-2002_11
특허 번호
US06479519B1

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