Pyridine → 4-Oxo-undecanoyl Chloride

HRID 1018159

반응식

HRID 1018159 반응식
[O:1]=[C:2]([CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14])[CH2:3][CH2:4][C:5](O)=[O:6].N1C=CC=CC=1.S(Cl)([Cl:23])=O>CCOCC>[O:1]=[C:2]([CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14])[CH2:3][CH2:4][C:5]([Cl:23])=[O:6]

참가 물질

5

반응물 3

HCID 1049PyridineHCID 24386Thionyl ChlorideHCID 52829854-Oxoundecanoic acid

생성물 1

HCID 229905004-Oxo-undecanoyl Chloride

시약·촉매·용매 1

HCID 3283Diethyl Ether용매2회

실험 절차

To a suspension of 50 g 4-oxo-undecanoic acid (Synthesis, 1987, 408) in 350 ml of ether, 22.15 g pyridine was added in at 0° C. Then a solution of 32.72 g thionyl chloride in 50 ml of ether was added in at 0-5° C. and then the reaction mixture was stirred for 20 hours at room temperature. Then the reaction mixture was filtered and evaporated to dryness. The residue (53.83 g yellow oil) was not further purified.

후처리

  1. additionwas added in at 0° C
  2. filtrationThen the reaction mixture was filtered
  3. customevaporated to dryness

출처 및 근거

ORD 기록
ord-98508d6c7eda41d6817d6ff96e3bd20f
출처 데이터셋
uspto-grants-2002_11
특허 번호
US06479682B1

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