반응식
[CH:1]1([CH2:8][CH2:9][C:10](O)=O)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH:13]1([CH:19]=O)[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]1.[CH:21]1[C:30]2[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=2)C=CC=1C=O.C([O:40][C:41](=[O:49])[C:42]1[CH:47]=[CH:46][CH:45]=[C:44]([NH2:48])[CH:43]=1)C1C=CC=CC=1.C(OC(=O)C1C=C([NH2:75])C=C(C(OCC2C=CC=CC=2)=O)C=1)C1C=CC=CC=1.C[NH:78][CH2:79][C@@H:80]([C@H]([C@@H]([C@@H](CO)O)O)O)[OH:81].[OH2:90]>O.O1CCOCC1>[CH:1]1([CH2:8][CH2:9][C:10]2[NH:48][C:19]([CH:13]3[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18]3)=[N:78][C:79]=2[C:80]([OH:81])=[O:90])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7]1.[CH:1]1([CH2:8][CH2:9][C:10]2[NH:75][C:21]([CH:30]3[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29]3)=[N:78][C:79]=2[C:80]([NH:48][C:44]2[CH:43]=[C:42]([CH:47]=[CH:46][CH:45]=2)[C:41]([OH:40])=[O:49])=[O:81])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7]1참가 물질
반응물 7
생성물 2
시약·촉매·용매 1
실험 절차
5-(2-Cycloheptyl-ethyl)-2-cyclohexyl-1H-imidazole-4-carboxylic acid was prepared according to the procedure of Example 20, steps a, b and c, with the modification that cycloheptanepropionic acid was used instead of cycloheptaneacetic acid in step a, and cyclohexanecarboxaldehyde replaced 2-naphthaldehyde in step b. The acid was then converted to the title compound according to the procedure of Example 20, steps d and e, with the modification that 3-amino-benzoic acid benzyl ester replaced 5-amino-isophthalic acid dibenzyl ester in step d. 1H NMR (300 MHz, d6-DMSO) 12.00 (1H, br s), 9.58 (1H, s), 8.45 (1H, s), 7.88 (1H, m), 7.59 (1H, d), 7.38 (1H, t), 2.89 (2H, m), 2.70 (1H, m), 2.00 (2H, m), 1.75-1.35 (23H, m). The acid was converted to the N-methyl-D-glucamine salt and lyophilised from water/dioxan. Found: C, 60.15; H, 8.43; N, 8.58%. C33H52N4O8.1.4 mols H2O requires: C, 60.22; H, 8.40; N, 8.51%.
출처 및 근거
- ORD 기록
- ord-ca27623a49e244849047f51a7bccd8de
- 출처 데이터셋
- uspto-grants-2002_11
- 특허 번호
- US06479531B1
연결된 노트
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